川芎、黄芪对自发性高血压大鼠胸主动脉外膜成纤维细胞增殖的影响  

Effect of Ligustcum chuanxiong and Radix Astragalus on the Proliferation of Aortic Adventitial Fibroblasts in Spontaneously Hypertensive Rats

作　　者：钱岳晟[1] 李燕[1] 高平进[1] 顾天华[1] 张照英 吴永杰[1] 

机构地区：[1]上海第二医科大学附属瑞金医院上海市高血压研究所,上海200025

出　　处：《中国中西医结合杂志》2003年第S1期24-26,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：上海市教育委员会科学发展基金资助(No.99B13)

摘　　要：目的:探讨川芎、黄芪对自发性高血压大鼠(SHR)胸主动脉外膜成纤维细胞增殖的抑制作用。方法:以单用川芎或川芎黄芪合剂的 SHR 血清检测对培养的 SHR 胸主动脉外膜成纤维细胞~3H-胸腺嘧啶核苷(~3H-TdR)掺入的影响。结果:川芎和川芎、黄芪合用对 SHR 的血压和心率没有影响,川芎血清组和川芎黄芪合剂血清组与 SHR 血清组比较,~3H-TdR 的掺入量差异有显著性(P<0.05,P<0.01)。结论:川芎、黄芪能抑制 SHR 胸主动脉外膜成纤维细胞增殖,这些效应可能与它们的钙离子拮抗有关。Objective:To explore the inhibition of Ligustcum chuanxiong and Radix Astragalus on the proliferation of aortic adventitial fi- broblasts in spontaneously hypertensive rats (SHR).Methods:SHR serum with Ligustcum chuanxiong alone (group A)or with mix- ture of Ligustcum chuanxiong and Radix Astragalus (group B) were used to determine the effect of^3H-thymidine(~3H-TdR)incorpo- ration.Results:No influence of Ligustcum chuanxiong and mixture of Ligustcum chuanxiong & Radix Astragalus on the blood pres- sure and...

关 键 词：川芎 黄芪 血管外膜成纤维细胞 增殖 

分 类 号：R285.5[医药卫生—中药学]