猪慢性缺血心肌基因转染前后心肌灌注图像的研究  

Study of myocardial perfusion of porcine chronic ischemic myocardium before and after gene transfer

作　　者：赵宝珍[1] 徐静[1] 顾俊彦[2] 王忠[3] 陆世萍[1] 赵旭升[1] 

机构地区：[1]第二军医大学附属长海医院超声科,上海200433 [2]第二军医大学附属长海医院胸心外科,上海200433 [3]第二军医大学附属长海医院麻醉科,上海200433

出　　处：《中华超声影像学杂志》2003年第5期42-44,共3页Chinese Journal of Ultrasonography

摘　　要：目的　用声学造影技术观察猪慢性缺血心肌基因转染前后心肌灌注图像的变化。方法　将健康家猪 10头分为基因转染组 (6头 )和对照组 (4头 ) ,于正常状态 ,在冠脉回旋支放置Ameroid环 4周 ,缺血心肌局部注射携带VEGF B基因的重组腺病毒液、对照组局部注射磷酸盐缓冲液后 4周共 3次进行心肌声学造影 ,观察正常心肌、慢性缺血心肌和基因转染后心肌及对照组心肌声学造影图像变化。结果正常状态下左室心肌厚度均匀 ,声学造影图像色泽明亮 ;慢性缺血心肌变薄 ,声学造影图像基本不充填 ;基因转染 4周后局部心肌不均匀灌注 ;而对照组局部心肌回声仍低暗 ,内散在点状高回声。结论　猪慢性缺血心肌基因转染后 ,其局部心肌血供改善。Objective To observe the perfusion changes of porcine chronic ischemic myocardium before and after gene transfer by myocardial contrast. Methods Ten normal pigs were divided into two groups: groupⅠfor gene transfer(6 pigs) and groupⅡ for control(4 pigs). Myocardial contrasts were performed respectively in basic status, 4 weeks after an Ameroid constrictor was placed around the proximal left circumflex artery (LCX) and another 4 weeks after the replication deficient recombinant adenovirus coding for the v...

关 键 词：超声心动描记术 造影剂 心肌缺血 基因转移 

分 类 号：R445.1[医药卫生—影像医学与核医学]