黄芪与氯沙坦治疗临床期糖尿病肾病的对比研究  

Comparision of Efficacies of Radix Astragali and Losartan on Diabetic Nephropathy During Clinical Stage

作　　者：方文军[1] 秦利[1] 金杰[1] 左静南[1] 

机构地区：[1]上海第二医科大学附属新华医院内分泌科,上海200092

出　　处：《中国医师杂志》2003年第S1期70-72,共3页Journal of Chinese Physician

摘　　要：目的　比较黄芪与氯沙坦对临床期糖尿病肾病的疗效。方法　将血糖、血压控制比较理想的 68例临床期糖尿病肾病患者随机分为氯沙坦组 2 4例、黄芪组 2 6例和糖尿病肾病组 18例 ,疗程 8周。结果　⑴氯沙坦组治疗后 2 4h尿白蛋白、2 4h尿蛋白、尿 β2 -MG明显下降 (P均 <0 0 5 ) ,肾小球滤过率升高 (P <0 0 5 )。⑵黄芪能显著降低 2 4h尿白蛋白、2 4h尿蛋白、尿 β2 -MG(P均 <0 0 1) ,升高肾小球滤过率 (P <0 0 1) ,其效果明显强于氯沙坦 (P均 <0 0 5 )。⑶糖尿病肾病对照组 2 4h尿白蛋白、2 4h尿蛋白、尿 β2 -MG、肾小球滤过率则无明显变化 ( P 均 >0 0 5 )。Objective To compare the efficacies of RA and losartan on diabetic nephropathy during clinical stage 68 patients with diabetic nephropathy during clinical stage who were good controlled in blood glucose,blood pressure in clinical periods,were randomly divided into losartan group( n =24),RA group( n =26) and diabetic nephropathy group( n =18) the treatment course was 8 weeks.Methods .Results ⑴24h urine albumin,uraneprotein,urine β-microglobulin(β-MG) in 24h were all reduced (all P <0.01),glomerular fi...

关 键 词：糖尿病肾病 氯沙坦 黄芪 

分 类 号：R587.2[医药卫生—内分泌]