老年高血压病患者内皮素和一氧化氮的变化以及伊贝沙坦的影响  

Effect of Irbesartan on Plasma Endothelin-1 and Nitrogen Monoxide in Elderly Patients with Essential Hypertension

作　　者：梁创[1] 陈耀伟 

机构地区：[1]广东省遂溪县人民医院,广东遂溪524300 [2]广东省湛江市中心人民医院

出　　处：《中国医师杂志》2003年第S1期48-49,共2页Journal of Chinese Physician

摘　　要：目的　探讨老年中重度原发性高血压患者血液内皮素 -1和一氧化氮的变化以及伊贝沙坦对这些变化的影响。方法　分为两组 :伊贝沙坦组为年龄在 60岁以上 ,经应用两种以上降压药物治疗后 ,收缩压仍≥ 160mmHg或舒张压≥ 10 0mmHg的患者 ,共 40例。在原治疗的基础上加用伊贝沙坦 15 0mg/d ,共 6周 ,观察加用伊贝沙坦治疗前后的血浆内皮素 -1(ET -1)和一氧化氦(NO)水平的变化。并设健康对照组 40名。结果　经伊贝沙坦治疗后ET -1明显下降 ,血浆NO水平比加药前升高。与对照组比较 ,ET -1加药前后均高于对照组 ;NO加药前比对照组低 ,加药后比对照组高 ,而ET -1/NO的比值 ,加药后比加药前降低 ,并达到正常对照组水平。结论　伊贝沙坦可能有助于改善患者的血管内皮功能和血管的收缩与舒张的平衡功能。Objective To investigate effect of Irbesartan on plasma endothelin-1 (ET-1) and nitrogen monoxide (NO) in elderly patients with moderate to severe essential hypertension.Methods Forty patients with essential hypertension who were ≥60 years of age and had been treated with two or more antihypertensive drugs but whose systolic pressure were ≥160 mmHg and or whose diastolic pressure were ≥100mmHg,entered into the present study. Irbesartan 150mg daily was added to their original treatment for 6 week. E...

关 键 词：伊贝沙坦 内皮素 一氧化氮 

分 类 号：R544.1[医药卫生—心血管疾病]