SAS-A技术制备聚乙二醇微粒  

Production of Polyethylene Glycol Microparticles Using a SAS-Atomization Drying Process

作　　者：蒋茂星[1] 王金献[1] 赵磊[1] 苏玉忠[1] 王宏涛[1] 李军[1] 

机构地区：[1]厦门大学化学化工学院化学工程与生物工程系,福建厦门361005

出　　处：《化学工程与装备》2008年第3期11-18,共8页Chemical Engineering & Equipment

摘　　要：超临界流体抗溶剂-雾化(SAS-A)技术研究用聚乙二醇(PEG6000)/乙醇/水体系制备聚乙二醇(PEG)微粒。探讨预膨胀压力、溶液浓度和溶液流量等工艺参数对微粒形貌及粒径的影响;重点探讨SAS-A技术中使用不同溶剂对颗粒形态和粒径分布的影响。结果表明,以丙酮和乙醇为溶剂的SAS-A技术可以制得形态基本上为球形的PEG微粒,粒径分布分别可以控制在1~5μm和2~15μm之间;增大预膨胀压力容易得到分散的球形微粒,并能减小微粒粒径,微粒粒径分布也随之变窄。对应PEG/丙酮体系,溶液浓度升高,所得到的微粒粒径增大;对应PEG/乙醇体系,溶液浓度对粒径大小影响不大,但溶液浓度增大会使粒径分布变宽。采用乙醇水溶液为溶剂时,初始乙醇浓度越低,移出水的效果越差,易形成结块的不规则微粒。Supercritical anti-solvent (SAS)-atomization process was employed to produce Polyethylene Glycol particles from PEG6000/ethanol/water solutions. The effect of different process parameters on the morphology and the size of the produced PEG particles, including the operating pressure, the protein concentration and the flow-rate of the protein/ethanol/water feed had been studied, especially the influence of various solvents were evaluated. The PEG particles produced form acetone and ethanol were generally sphe...

关 键 词：二氧化碳 微粒 聚乙二醇 超临界流体 

分 类 号：TQ316.3[化学工程—高聚物工业]