血府逐瘀汤对急性坏死性胰腺炎血清胰岛素和胰高血糖素影响的实验研究  

Effects of Chinese Medicine Xuefuzhuyuchang on the Level of Serum Insul and Glucagon in Acute Necrotizing Pancreatitis in Rabbits

作　　者：曹光誉[1] 邹锦慧[1] 彭卫[1] 李道清[1] 张慧明[1] 

机构地区：[1]韶关学院医学院附属新华医院中医科,广东韶关512026

出　　处：《中国医疗前沿（学术版）》2008年第1期20-21,31,共3页China Healthcare Innovation

基　　金：韶关市科技计划项目;编号2007-37

摘　　要：目的研究血府逐瘀汤对急性坏死性胰腺炎血清胰岛素和胰高血糖素的影响。方法逆行胰管注射5%的牛磺胆酸钠制作急性坏死性胰腺炎模型。于3h、9h、24h、48h取标本观察各组血清胰岛素、胰高血糖素的改变,及胰腺的病理学形态改变。结果与ANP组(30.31±7.27mIU/mL,19.54±6.25mIU/mL)比较,中药治疗组(50.95±6.33mIU/mL,47.67±6.94mIU/mL)血清胰岛素水平在24h、48h相比恢复正常,差异有统计学意义(P<0.05)。与ANP组(2.98±0.43,2.87±0.44)比较,中药治疗组(2.16±0.31ng/mL,2.07±0.29ng/mL)血清胰高血糖素水平在24h、48h相比恢复正常,差异有统计学意义(P<0.05)。中药治疗组胰腺间质水肿,炎性浸润减少,腺泡细胞胞浆空减少,胰岛细胞无明显病理改变。结论血府逐瘀汤具有显著改善急性胰腺炎早期内分泌功能损伤的作用。Objective:To investigate the therapeutic effects of Chinese Medicine Xuefuzhuyuchang on the level of serum insulin and glucagon in rabbits.Methods Retrograde pancreatic duct injection of 5 % sodium taurocholate 1. 0 ml·kg-1 was used to establish ANP models and rabbits were sacrificed at 3 h, 9 h, 24 h, 48 h after induction of pancreatitis. All rabbits were randomly divided into three groups: the control group (Group A,n =15),the ANP group (Group B,n =20),and the ANP with Chinese Medicine group (Group C,n =2...

关 键 词：急性胰腺炎 血清胰岛素 胰高血糖素 中药 

分 类 号：R285.5[医药卫生—中药学]