自体骨软骨移植修复兔膝关节软骨的早期生物力学评价  

Biomechanical properties of the repaired tissue of rabbit knee articular cartilage by autologous osteochondral transplantation

作　　者：伏治国[1] 董启榕[1] 许波[1] 杨勇[2] 杨城成[2] 

机构地区：[1]苏州大学附属第二医院骨科,苏州215004 [2]苏州大学物理实验中心,苏州215006

出　　处：《医用生物力学》2008年第5期347-352,388,共7页Journal of Medical Biomechanics

基　　金：卫生部科学研究基金题(WKJ2004-2-009)

摘　　要：目的采用自体骨软骨移植系统(Osteochondral Autograft Transfer System,OATS)修复软骨缺损,术后12w比较修复软骨与正常关节软骨的压缩力学特性,观察修复软骨的组织学结构。方法18只新西兰兔右膝股骨滑车造成骨软骨缺损,取滑车临近部位相同直径和厚度的骨软骨柱修复缺损,左膝作为正常对照。术后12w取修复软骨和左膝对应部位正常软骨标本,12只动物的软骨标本采用非限制性压缩实验,分别应用线弹性模型和线性双相性模型计算修复软骨和正常关节软骨的杨氏模量和平衡压缩模量,记录应力松弛时间和蠕变时间,采用配对t检验对两组软骨的力学参数进行比较。另3只动物的软骨标本分别行HE染色和甲苯胺蓝染色,光镜下观察修复软骨的组织学结构。结果两组软骨的杨氏模量和平衡压缩模量、应力松弛时间、蠕变时间的差异均没有显著性(P<0.001)。修复软骨光镜下的组织学结构与正常软骨无明显差别。结论OATS修复关节软骨缺损的近期效果比较满意,但中远期修复效果还需进一步研究。Objective To evaluate the disparity of compressive biomechanical properties and the histological structures between the repaired cartilage and the normal ones were examine 12 weeks after autologous osteochondral transplantation.Methods 18 New Zealand white rabbits were selected and a full-thickness cylindrical osteochondral defect was made on the right knee femoral trochlea of each by using Osteochondral Autograft Transfer System(OATS).The defect was repaired with the osteochondral plug with the same diamet...

关 键 词：关节软骨 镶嵌式成形术 生物力学 组织学结构 

分 类 号：R687.3[医药卫生—骨科学]