近红外光谱技术对创伤性脑水肿的在体微创监测研究  

Study on mininvasive monitoring of traumatic brain edema in vivo by near-infrared spectroscopy

作　　者：何亮[1] 游洋[1] 杨天明[1] 钱志余[2] 郭丽娜[2] 毛雯岚[2] 吴琦[1] 

机构地区：[1]东南大学附属中大医院神经外科,江苏南京210009 [2]南京航空航天大学生物医学工程系,江苏南京210016

出　　处：《现代医学》2008年第4期221-224,共4页Modern Medical Journal

基　　金：国家自然科学基金资助项目(30671997)

摘　　要：目的探讨利用近红外光谱技术对创伤性脑水肿的发生发展规律进行微创在体监测的新方法。方法采用Feeney′s自由落体撞击法建立大鼠急性局灶性脑挫裂伤模型,以近红外光谱技术和干湿相对密度法监测创伤后脑水肿的变化。结果伤后1 h伤侧脑组织已发生水肿,伤后24~72 h伤侧脑水肿达高峰,随后逐渐减轻。对侧脑水肿的变化规律与伤侧相同,但水肿程度远轻于伤侧。近红外光谱监测的组织光学参数(μ′s)与脑水含量变化规律一致。结论μ′s是监测创伤性脑水肿的良好指标,近红外光谱技术可以用于在体微创监测创伤性脑水肿的变化。Objective To explore a new method of mininvasive monitoring the development of traumatic brain edema in vivo.Methods Acute regional brain trauma was applied according to Feeney′s apparatus.The changes of brain edema were monitored by near-infrared spectroscopy(NIRS) technology and by measuring the brain water content.Results Distinct brain edema in injured areas was found at 1 hours after trauma,which reached a summit of severity at 24-72 hours after trauma,then gradually declining.Changes in the contralate...

关 键 词：近红外光谱 创伤性脑水肿 微创监测 大鼠 

分 类 号：R651.15[医药卫生—外科学]