血栓前体蛋白、P选择素和D-二聚体三者联检在早期DIC诊断中的应用  

Combined Determination of Thrombus Precursor Protein、P Selectin and D-Dimer in Patients with DIC

作　　者：顾猛[1] 刘春霞[1] 张孔志[1] 张虹[1] 

机构地区：[1]南通瑞慈医院检验医学中心,江苏南通226010

出　　处：《中国血液流变学杂志》2008年第3期420-422,共3页Chinese Journal of Hemorheology

摘　　要：目的探讨血栓前体蛋白(TpP)、P选择素和D-二聚体(D-D)含量在弥漫性血管内凝血(DIC),特别是其早期发生过程中的变化。方法采用ELISA法检测DIC患者及正常对照组血浆中TpP、P选择素和胶体金法检测D-D的含量。同时对8例重型DIC患者血浆中三指标进行了为期10d的动态监测。应用受试者特性曲线(receiver operating characteristic curve,ROC)对三指标进行了比较和评价。结果血浆中TpP、P选择素和D-D的含量在DIC组和pre-DIC组均显著增高,与对照组比较均有显著差异(P<0.001)。动态观测中,P选择素和TpP出现较早。DIC早期诊断中敏感指标依次为P选择素、TpP和D-D,而特异性指标依次为TpP、D-D和P选择素,而三者联检可以使其检测特异性和灵敏度分别达到91.6%和94.4%。结论三者联检可以用于早期发现和诊断DIC,且TpP因出现较早且随着治疗的过程能同步变化,可作为一较理想的动态监测指标。Objective To observe clinical change of plasma Thrombus Precursor Protein (TpP),P selectin and D-Dimer levels in patients with DIC,especially in pre-DIC patients.Methods The three indexes were measured in 32 cases of patients with DIC,39 cases of patients with pre-DIC and 40 cases of normal controls.8 patients with DIC were continuously monitored for 10 days.Results All the levels of these three indexes in the pre-DIC group and DIC group were significantly higher than those in normal control group (P<0.0...

关 键 词：血栓前体蛋白 P选择素 D-二聚体 早期弥漫性血管内凝血 

分 类 号：R55[医药卫生—血液循环系统疾病]