复方鼠尾草注射液对心肌缺血再灌注大鼠心电图的影响  

Electrocardiogram Affected by Compounded Injections Made from Salvia Herbs in Ischemia/Reperfusion Rats

作　　者：苏彦宏[1] 段为钢[2] 李惠兰[3] 张荣平[4] 

机构地区：[1]昆明医学院第一附属医院心内科,云南昆明650031 [2]云南中医学院药理教研室,云南昆明650200 [3]昆明医学院药理教研室,云南昆明650031 [4]昆明医学院药学系,云南昆明650031

出　　处：《中国血液流变学杂志》2008年第2期194-196,236,共4页Chinese Journal of Hemorheology

基　　金：云南省科委应用基础研究基金(98C067M);云南省教育厅应用基础研究基金(03Y498C)资助

摘　　要：目的观察复方鼠尾草注射液(褐毛甘西鼠尾及甘西鼠尾与三七的复方制剂)对大鼠心肌缺血再灌注损伤的保护作用及心电图的变化。方法采用大鼠冠脉结扎法建立大鼠心肌缺血再灌注模型,探讨复方鼠尾草注射液对缺血再灌注大鼠心电图及心肌梗死面积的影响。结果两种鼠尾草注射液均能显著对抗缺血再灌注所致大鼠心电图ST段的抬高,缩小缺血再灌注心肌的梗死面积。结论对缺血再灌注损伤心肌的保护作用相似于复方丹参注射液。Objective To observe cardio-protection of compounded injections made from two Salvia herbs [Hemaoganxishuwei (Salvia przewalskii Maxim. var mandarin-norum stib.) and Ganxishuwei (Salvia przewalskii Maxim) with Sanqi (Panax notoginseng (Burk.) F.H. Chen)] against ischemia/reperfusion injury in rats, especially the changes in electrocardiogram during ischemia/reperfusion.Methods Ischemia/reperfusion model was established by coronary artery ligation, different injections were applied before and after ischemia,...

关 键 词：褐毛甘西鼠尾 甘西鼠尾 心肌缺血再灌注损伤 保护作用 

分 类 号：R285.5[医药卫生—中药学]