阻塞性睡眠呼吸暂停患者血液流变学及超敏C-反应蛋白的研究  

Study on the Hemorheology and High-sensitivity C-reactive Protein in Patients with Obstructive Sleep Apnea Syndrome

作　　者：杨晓玲[1] 李飞[1] 谷德祥[1] 

机构地区：[1]上海市市东医院神经内科,上海200438

出　　处：《中国血液流变学杂志》2008年第2期212-214,共3页Chinese Journal of Hemorheology

摘　　要：目的探讨阻塞性睡眠呼吸暂停(OSAS)患者的血液流变学及超敏C-反应蛋白(hsCRP)的改变。方法依据多导睡眠仪的呼吸暂停低通气指数(AHI)将患者分为4组:正常对照组(AHI<5)、轻度OSAS组(5≤AHI<20)、中度OSAS组(20≤AHI<40)、重度OSAS组(AHI≥40),对各组患者血液流变学和hsCRP进行检测。结果轻度OSAS组hsCRP高于对照组;中度OSAS组的hsCRP、全血粘度、血浆粘度、纤维蛋白原明显高于对照组;重度OSAS组hsCRP、全血粘度、血浆粘度、红细胞压积、纤维蛋白原均明显高于对照组。hsCRP、SaO2<90%所占百分比、纤维蛋白原、红细胞压积均与AHI呈正相关(r=0.326;0.458;0.353;0.410)。结论OSAS患者的hsCRP升高,血液流变学异常,且与OSAS的严重程度呈正相关。OSAS是心脑血管疾病的危险因素。Objective To investigate the changes of hemorheology and plasma high-sensitivity C-reactive protein (hsCRP) in patients with obstructive sleep apnea syndrome(OSAS).Methods All patients were diagnosed and di- vided into four groups by polysomngram according to AHI.20 adults without OSAS (AHI<5) were chosen to control group.21 patients (5≤AHI<20) were chosen to mild OSAS group and 28 patients (20≤AHI<40 ) to moderate OSAS group and 20 patients (AHI≥40) to severe OSAS group.Whole blood viscosity(high ...

关 键 词：阻塞性睡眠呼吸暂停 血液流变学 HSCRP 多导睡眠仪 

分 类 号：R766[医药卫生—耳鼻咽喉科]