虎杖对栓塞性肺动脉高压动物的作用  

Effect of Polygonum Ccuspidatum on Acute Thromboembolic Pulmonary Hypertension

作　　者：杨玲[1] 邱丽君[1] 周琪[1] 王佳[1] 林建海[1] 

机构地区：[1]上海交通大学医学院附属新华医院,上海200092

出　　处：《中国血液流变学杂志》2008年第1期24-26,共3页Chinese Journal of Hemorheology

摘　　要：目的研究中药虎杖对栓塞性肺动脉高压的作用。方法测定栓塞性肺动脉高压的小猪静脉注射虎杖前后的血液动力学、NO、纤溶酶-抗纤溶酶复合物(PAP)和血气分析及DD的变化,与对照组作比较。结果用虎杖后,肺动脉压显著下降,心搏指数增加,血氧分压改善,NO、PAP下降,与对照组比较有差异(P<0.05)。结论中药虎杖可明显降低栓塞引起的肺动脉高压,增加心输出量,改善氧合。Objective To investigate the effect of Polygonum ccuspidatum on pigs with acute thromboembolic pulmonary hypertension.Methods An animal model of acute pulmonary embolism was established by intravenous infusion of autologous blood clot.25 model pigs were randomly assigned to either Polygonum ccuspidatum treated (Polygonum ccuspidatum,n=15) or control (n=10) group.In 2 groups,systolic pulmonary artery pressure (SPAP), systolic artery blood pressure (SABP),cardiac index (CI),heart rate (HR),blood gas analysis,...

关 键 词：肺栓塞 肺动脉高压 虎杖 

分 类 号：R285[医药卫生—中药学]