幽门螺杆菌感染与门脉高压性胃病的发病关系  

RELATIONSHIP BETWEEN PORTAL HYPERTENSION GASTROPATHY AND Helicobacter pyroli INFECTION

作　　者：谭颖慧[1] 朱晓敏[1] 白玲[2] 张昶[2] 吴昊 

机构地区：[1]沈阳医学院微生物教研室,辽宁沈阳110034 [2]连云港市第一人民医院病理科,江苏连云港222002

出　　处：《微生物学杂志》2002年第3期20-21,共2页Journal of Microbiology

摘　　要：为了解门脉高压性胃病 (portalhypertensivegastropathyPHG)与幽门螺杆菌 (HP)感染的关系 ,选门脉高压性胃病胃窦粘膜 30例 ,免疫组化SP法 (链霉菌抗生物素蛋白—过氧化酶法 ,Streplavidin Peroxidase,SP)抗HP抗体染色 ,并以慢性乙型肝炎并胃病 2 0例及非肝病胃病 2 1例胃窦粘膜作对照。结果显示 ,30例门脉高压性胃病阳性2 2例 ,占 73.3% ;2 0例慢乙肝组阳性 11例 ,占 5 5 % ;2 1例非肝病组阳性 11例 ,占 5 2 .38%。门脉高压组HP感染阳性率与慢乙肝组、非肝病组相比差异无显著性 (P >0 .0 5 )。可见HP感染虽不是门脉高压性胃病的发生原因 ,但在治疗中短期加用杀HP的药物是必要的。In order to understand relationship between portal hypertension gastropathy (PHG) and Helicobacter pyroli (HP) infection, 30 cases of gastric antrum mucosa from patients who suffered from portal hypertension gastropathy (PHG), and stained the mucosa with immuno histo chemical SP(Streplavidin Peroxidase) method by anti HP antibody. Set 20 cases of gastric antrum mucosa from patients suffered from chronic HBV hepatitis and complicated with gastropathy, and 21 cases of gastric antrum mucosa from non hepatosis gastropathy as two control groups. The results showed that 22 out of 30 cases of PHG were positive HP infection accounted for 73.3%; 11 out of 20 cases of chronic HBV hepatitis complicated with gastropathy were positive HP infection accounted for 55%, while 11 out of 21 cases of non hepatosis gastropathy were positive HP infection accounted for 52.5%. It is thus clear that there were no clearly difference of HP infection rate among experimental and control groups; therefore, HP infection is not the cause that induces the PHG, yet it is necessary to take HP killing medicines in a short time during PHG treatment.\;

关 键 词：门脉高压 胃粘膜 幽门螺杆菌 免疫组化 

分 类 号：R378.2[医药卫生—病原生物学]