前列腺素E1与西地那非治疗ED的比较  

Prostaglandin E1 versus Sildenafil in the Management of Erectile Dysfunction

作　　者：王振林[1] 李彬[2] 闫靖中[1] 董胜国[1] 

机构地区：[1]青岛大学医学院附属医院泌尿外科,山东青岛266003 [2]胶南市人民医院外科,山东胶南266400

出　　处：《中华男科学杂志》2002年第3期198-200,共3页National Journal of Andrology

摘　　要：目的 :比较口服西地那非与阴茎海绵体内注射前列腺素E1(PGE1)治疗勃起功能障碍 (ED)的疗效。　方法 :5 4例ED病人随机分为两组 ,A组口服西地那非 ,B组行海绵体内注射PGE1,均治疗 4～ 9个月 ,平均 6个月。结果 :A、B两组的有效率分别为 80 0 %和 83 3% ,两者差异无显著性 (P >0 0 5 )。A组 6例无效病人经海绵体内注射PGE1治疗 ,2例获得满意勃起 ;而B组 4例无效病人经口服西地那非治疗 ,无 1例勃起。　结论 :口服西地那非与海绵体内注射PGE1对各种病因所致的ED均有良好的治疗作用 ,对西地那非治疗无效者 ,可试用海绵体内注射PGE1。Objectives: To evaluate the outcome of treatment in patients with erectile dysfunction (ED) using sildenafil or intracavernosal injection of prostaglandin E1(PGE1). Methods: 54 patients with ED were randomly classified into two groups and received either oral sildenafil (group A) or intracavernosal injection of PGE1(group B) for 4～9 months with an average of 6 months. Results: The percentages of efficacy in the two groups were 80.0%and 83.3%, respectively. There was no statistical difference between group A and B ( P >0.05). Two of six patients who did not respond to sildenafil in group A achieved erections sufficient for sexual intercourse when the six patients received intracavernous injection of PGE1. None of the four patients who did not respond to intracavernous injection of PEG1 in group B achieved erection sufficient for sexual intercourse when they received oral sildenafil. Conclusions: Both oral sildenafil and intracavernous injection of PGE1 are effective for patients with ED of various etiologies. The patients who do not respond to sildenafil can receive intracavernous injection therapy. The satisfactory results can probably achieved.

关 键 词：勃起功能障碍 西地那非 前列腺素E1 

分 类 号：R698.1[医药卫生—泌尿科学]