广藿香挥发油对抗青蒿酯钠伯氏疟原虫膜脂质流动性的影响  

Effect of Palchouli Volatile Oil on Membranous Lipid Fluidity of Sodium Artesunate Resistant Plasmodium Berghei

作　　者：隋在云[1] 吕丽莉[1] 刘爱如[1] 于宗渊[1] 

机构地区：[1]山东省中医药研究所药理研究室,济南250014

出　　处：《中国中西医结合杂志》2002年第S1期209-210,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家中医药管理局资助项目(No.94B053)

摘　　要：目的:探讨广藿香挥发油对抗青蒿酯钠伯氏疟原虫选择性抗疟作用的机理。方法:以1,6-二苯己三烯(DPH)为荧光探针,研究广藿香挥发油对伯氏疟原虫正常株和抗青蒿酯钠株膜脂质流动性的影响。结果:给药前抗青蒿酯钠伯氏疟原虫膜脂质流动性明显低于正常株(P<0.01)。给药后两者的膜流动性均增加(P<0.01);且两者间的差异无显著性(P>0.05)。结论:广藿香挥发油可能改变了抗青蒿酯钠疟原虫膜的功能,使其膜流动性明显增加。Objective:To study the mechanism of selective antimalarial effect of Palchouli volatile oil(PVO)on radium artesunate resistant (SAR)plasmodium Berghei(PB).Methods:The effect of PVO on membranous lipid fluidity in general strain of PB and in SAR strain of PB(SAR-PB)was measured with 1,6-diphenyl-1,3,5-hexatriene(DPH)fluorescence probe.Results:Membranous lipid fluidity in SAR-PB was lower than that in general PB(P<0.01),which increased in both groups treated with PVO(P<0.01),and the differ- ence between...

关 键 词：广藿香挥发油 伯氏疟原虫正常株 伯氏疟原虫抗青蒿酯钠株 膜脂质流动性 

分 类 号：R285.5[医药卫生—中药学]