解瘀通络肝炎灵对慢性实验性肝损伤的治疗作用  

Study on Therapeutic Effect of Jieyu Tongluo Ganyanling on Experimental Chronic Liver Injury

作　　者：洪云玉[1] 朴瑛[1] 崔银香[1] 金花善[1] 朴熙绪[2] 裴凤郁[2] 

机构地区：[1]吉林省延吉市延边第二人民医院消化内科,吉林延吉133000 [2]延边大学医学院附属医院消化内科

出　　处：《中国中西医结合杂志》2002年第S1期146-148,共4页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的:初步探讨解瘀通络肝炎灵的治疗作用。方法:将61只健康 Wistar 大鼠随机分为正常对照组,模型组,乙肝宁组,解瘀通络肝炎灵大、中、小剂量组,通过建立 CCl_4诱导的大鼠慢性实验性肝损伤模型,观察解瘀通络肝炎灵对肝功能生化指标、血清透明质酸、肿瘤坏死因子α及肝脏病理组织学等影响。结果:与模型组比较解瘀通络肝炎灵能明显改善肝功能生化指标,降低血清透明质酸和肿瘤坏死因子α浓度,减轻光镜下的肝脏病理组织学变化。与乙肝宁组比较,其各项指标相似或略占优势。结论:提示解瘀通络肝炎灵对慢性肝损伤改善肝功能生化指标。肝纤维化血清学指标及免疫功能,肝脏病理组织学改善有良好的疗效。Objective:To study the therapeutic effect of Jieyu Tongluo Ganyanling(JTG)on treatment chronic liver injury.Methods:Sixty healthy Wistar rats were randomly divided into the normal control group,the CCl_4 injured group,the Yiganning group and the JTG groups of high,middle and low dose.The effect of JTG on indices of liver function,hyaluronic acid(HA),tumor necrosis factor α (TNF-α)and pathological change of liver tissue were observed.Results:As compared with the model group,results showed significant improvi...

关 键 词：解瘀通络肝炎灵 慢性肝损伤 肿瘤坏死因子Α 透明质酸 

分 类 号：R285.5[医药卫生—中药学]