筛选抗HBsAg中草药的实验研究  

Experimental Study on Screening of Chinese Herbal Medicine for Anti-Hepatitis B Surface Antigen(HBsAg)

作　　者：谢志眷[1] 陈智平[1] 邬质彬[1] 苏洁寒[1] 

机构地区：[1]广西医科大学公共卫生学院,南宁530021

出　　处：《中国中西医结合杂志》2002年第S1期139-141,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：本课题受广西自治区科技厅科学基金资助(No.9811002);广西医科大学科研基金(2002)资助

摘　　要：目的:筛选具有抑制乙型肝炎表面抗原(HBsAg)活性的中草药。方法:体外试验采用反向间接血凝法,动物实验采用本室自己建立的乙型肝炎树鼩感染模型。结果:通过体外试验,从200种常用中草药中筛选出具有较明显抑制 HBsAg 活性的5种药物,即叶下珠、桑椹子、五倍子、丹参和仙茅,这些药物最多可使 HBsAg 滴度从1:32768降至1:16。该5种药物经进一步在树鼩体内进行抗乙肝病毒抑制试验,结果仅有叶下珠和五倍子有清除 HBsAg 作用,各有3只树鼩分别服用叶下株和五倍子,结果每组各有2只动物 HBsAg转阴。结论:叶下珠及五倍子具有较强抗 HBsAg 作用,值得进一步作临床疗效的评价。Objective:To screen the Chinese herbal medicines for anti-hepatitis B surface antigen(HBsAg).Methods:The self-established tree shrew model of hepatitis B infection was used to observe the anti-hepatitis B surface antigen(HBsAg)effect by inverse indirect hemag- glutination method in vitro.Results:From 200 kinds of herbs,5 kinds with significant inhibitory effect were screened out,they were Phyllanthus urinaria,Fructus Morus,Calla Melaphis chinehsis,Radix Salviae miltiorrhizae and Rhizoma Curculig.These drugs...

关 键 词：乙型肝炎表面抗原 中草药 体外试验 树鼩 

分 类 号：R285.5[医药卫生—中药学]