大鼠脾气虚证模型形成过程中子宫血管舒张—收缩因子的改变  

Changes of Vasodilatory and Vasocontrictory Factors of Uterus in the Modeling Process of Spleen Deficiency Syndrome Rat Model

作　　者：陈易新[1] 陈家旭[1] 季绍良[1] 刘晓兰[1] 瞿德竑[1] 赵歆[1] 徐洪雁[1] 康纯洁[1] 刘燕[1] 

机构地区：[1]北京中医药大学,北京100029

出　　处：《中国中西医结合杂志》2002年第S1期132-135,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：高等学校博士专科点专项科研基金;国家中医药管理局资助课题(No.2000-J-B-20)

摘　　要：目的:探讨雌性大鼠在泻下一劳倦复合因素作用下,对子宫血管舒张一收缩因子[内皮素(ET)-一氧化氮(NO)]的改变,以及益气止血中药对其影响。方法:采用番泻叶泻下—游泳劳倦复合因素建立脾气虚动物模型,并运用益气止血中药予以治疗干预。结果:雌性大鼠在脾气虚状态下,子宫 ET、NO 及卵巢、子宫重量均有明显有意义变化,益气止血复方拆方及复方都对各指标均有一定调节作用。结论:脾气虚状态下,会引起雌性大鼠的生殖系统的变化,并且出、凝血系统的某些环节受到影响,而再附加特定出血因素时会引起出血倾向,从而从一定程度上证实脾气虚是脾不统血证发生的基础。Objective:To explore the changes of uterus vasodilatory and vasocontrictory factors[endothelin(ET)and nitric oxide(NO)]un- der the action of complex factors with purgation and fatigue,and the effect of Chinese herbal medicine for supplementing Qi and arrest- ing hemorrhage(SQAH)on them.Methods:The Spleen-Deficiency Syndrome(SDS)model was established by applying the complex factors with Cassia angustifolia induced purgation and fatigue by swimming,and the process of modeling was intervened by SQAH treatment,...

关 键 词：脾虚 动物模型 血管舒张因子 血管收缩因子 出血 

分 类 号：R256.3[医药卫生—中医内科学]