黄芪与川芎在治疗自发性高血压大鼠中的相互作用研究  

Study on Interaction between Astragalus and Ligusticum in Spontaneous Hypertension Rats

作　　者：顾天华[1] 钱岳晟[1] 张照英[1] 吴永杰[1] 罗雪美[1] 

机构地区：[1]上海第二医科大学附属瑞金医院上海市高血压研究所,上海200025

出　　处：《中国中西医结合杂志》2002年第S1期16-18,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：上海市教育委员会科学发展基金资助(No.99B13)

摘　　要：目的:观察黄芪与川芎在治疗自发性高血压大鼠(SHR)中的相互作用。方法:在 SHR 模型给予黄芪、川芎合用与单用川芎,以离体主动脉环反应性、血清一氧化氮(NO)及血浆内皮素(ET)浓度以及组织血流等指标观察其不同的反应。结果:黄芪、川芎合剂或单用川芎均不影响大鼠血压;单用川芎可使去或不去内皮的胸主动脉环对苯肾上腺素的收缩反应降低,在去内皮的胸主动脉环,这种收缩反应降低作用在两药合用后消除;单用川芎还能使 SHR 血清 NO 升高和肾皮质血流增加,这些作用在合用黄芪后也被消除或减轻。结论:黄芪能对抗或部分对抗川芎在 SHR 的药理作用,这种对抗作用的意义及机制值得进一步研究。Objective:To study the interaction between Astragalus membranaceus and Ligusticum wallichi in spontaneous hypertension rats (SHR).Methods:SHR was treated with ligusticum alone or combined with Astragalus,and the effects on reaetivlty of isolated aortic ring,level of serum nitric oxide(NO),plasma endothelin(ET)and blood flow in tissue were observed.Results:Ligusticum used alone or combined with Astragalus didn t influence the blood pressure.Ligusticum used alone could reduce the contractive response of aorti...

关 键 词：黄芪 川芎 主动脉环 血流量 一氧化氮 

分 类 号：R285.5[医药卫生—中药学]