健脑合剂对小鼠急性脑缺氧的保护作用及学习记忆障碍的改善作用  

Effect of Jiannao Mixture on Protecting Mice from Acute Cerebral Ischemia and Improving Learning and Memory Deficits

作　　者：史红[1] 张望刚[1] 钱伯初[1] 

机构地区：[1]浙江省医学科学院药物研究所,杭州310013

出　　处：《中国中西医结合杂志》2002年第S1期55-57,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：浙江省中医药管理局资助项目(No.1999ZY18)

摘　　要：目的:观察中药健脑合剂对正常小鼠急性脑缺氧的保护作用及记忆障碍小鼠学习记忆的改善作用,并初步探讨其作用机理。方法:采用常压缺氧、亚硝酸钠缺氧及断头缺氧法观察健脑合剂对正常小鼠急性脑缺氧的保护作用;用跳台法、避暗法检测健脑合剂对由东莨菪碱、亚硝酸钠及乙醇所致记忆障碍小鼠的学习记忆能力的影响。结果:健脑合剂14g/kg 和28g/kg 对常压缺氧、亚酸钠缺氧及断头缺氧显示出显著延长急性脑缺氧状态下小鼠的生存时间的作用;同时显著增强小鼠被动学习能力,改善由东莨菪碱、亚硝酸钠及乙醇所致记忆获得、记忆巩固及记忆再现障碍。结论:中药健脑合剂对正常小鼠急性脑缺氧具有较好的保护作用并可改善记忆障碍模型小鼠学习记忆功能,其机制可能与提高大脑血氧水平、影响中枢 M 胆碱能系统等有关。Objective:To observe the effect of Jiannao Mixture(JNM)in protecting mice from acute cerebral ischemia and improving learning and memory deficits.Methods:Acute cerebral ischemia in mice was induced by anoxia under ordinary pressure,sodium nitrite anoxia or decollation anoxia to observe the protective effect of JNM.Step down test and step through test were used to test the effect of JNM in improving learning and memory in mice with memory deficit induced by scopolamine,sodium nitrite or alcohol.Results:JNM(1...

关 键 词：健脑合剂 脑缺氧 记忆障碍 小鼠 

分 类 号：R285.5[医药卫生—中药学]