调肝导浊中药对小鼠腹腔巨噬细胞一氧化氮及一氧化氮合酶含量影响的实验研究  

Experimental Study on Effect of Tiaogan Daozhuo(调肝导浊)Therapy on Content of Nitric Oxide and Its Synthase in Peritoneal Macrophage of Mice

作　　者：张柏丽[1] 陆一竹[1] 范英昌[1] 张莉[1] 

机构地区：[1]天津中医学院,天津300193

出　　处：《中国中西医结合杂志》2002年第S1期42-43,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：天津市自然科学基金(No.003607911)

摘　　要：目的:探讨调肝导浊中药防治动脉粥样硬化的机理。方法:运用体外培养技术,以加高脂血清和中药等不同培养基培养小鼠腹腔巨噬细胞,检测细胞培养液中一氧化氮(NO)、一氧化氮合酶(NOS)、氧化修饰低密度脂蛋白(OX-LDL)等指标。结果:调肝导浊中药可明显增加细胞培养液中 NO、NOS 的含量,并可抑制 OX-LDL 生成。结论:该中药通过对 NO、NOS、OX-LDL 含量的调节,阻止动脉粥样硬化(AS)的发生及发展。Objective:To study the mechanism of Tiaogan Daozhou(TGDZ)therapy in treating atherosclerosis.Methods:Peritoneal macrophage of mice were cultured in different culture media(with high lipid serum or/and different Chinese herbal medicines).Content of nitric oxide(NO),nitric oxide synthase(NOS),oxidative modified low density lipid(OX-LDL)in culture were determined.Results: TGDZ could markedly increase the content of NO and NOS in culture and inhibit the production of OX-LDL.Conclusion:TGDZ could arrest the occu...

关 键 词：调肝导浊中药 动脉粥样硬化 一氧化氮 一氧化氮合酶 氧化修饰低密度脂蛋白 

分 类 号：R285.5[医药卫生—中药学]