Chemical Constituents of Rheum tanguticum Maxim.ex Balf.  

唐古特大黄化学成分研究(英文)

作　　者：金伟[1] 格日立[2] 黄志勤[3] 魏全嘉[2] 包天佑[2] 屠鹏飞[1] 

机构地区：[1]北京大学医学部药学院,北京100083 [2]青海大学医学院,青海西宁810001 [3]赣南医学院,江西赣州341000

出　　处：《Journal of Chinese Pharmaceutical Sciences》2006年第4期206-210,共5页中国药学（英文版）

基　　金：Natural Research Foundation of Qinghai Province( No. 2004-N-103-02)

摘　　要：Aim To study the chemical constituents of the root and rhizome of Rheum tanguticum Maxim. ex Balf. Methods Chemical constituents were isolated and purified by many chromatographic methods, and their structures were elucidated by MS, NMR, and others. Results Twenty compounds were isolated and their structures were identified as β-sitosterol, chrysophanol, aloe-emodin, physcion, rhein, emodin, etc. Conclusion Among these compounds, 4-(4′-hydroxyphenyl)-2-butanone, 4-(4′-hydroxyphenyl)-2-butanone-4′-O-β-D-(2″-...目的研究唐古特大黄的化学成分。方法采用多种色谱技术进行分离纯化,应用质谱、核磁等技术确定化合物的结构。结果从唐古特大黄的根和根茎中分离得到β-谷甾醇、大黄酚、芦荟大黄素、大黄素甲醚、大黄酸、大黄素等20个化合物。结论 4′-羟基苯基-2-丁酮(9)、4′-羟基苯基-2-丁酮-4′-O-β-D-(2″-O-桂皮酰基-6″-O-没食子酰基)-葡萄糖苷(12)和4′-羟基苯基-2-丁酮-4′-O-β-D-(2″-O-没食子酰基-6″-O-(4″′-羟基)-桂皮酰基)-葡萄糖苷(13)为首次从该种植物中分离得到。

关 键 词：Rheum tanguticum Maxim ex Balf. 4-（4′-hydroxyphenyl）-2-butanone 4-（4′-hydroxyphenyl）-2-butanone-4′-O-β-D-（2″-O-cinnamoyl-6″-O-galloyl）-glucopyranoside 4-（4′-hydroxyphenyl）-2-butanone-4′-O-β-D-（2″-O-galloyl-6″-O-p-coumaroyl）-glucopyranoside. 

分 类 号：R284[医药卫生—中药学]