Chemical Constituents from Pueraria lobata  

野葛化学成分研究(英文)

作　　者：斯建勇[1] 常琪[1] 沈连钢[1] 陈迪华[1] 

机构地区：[1]中国协和医科大学中国医学科学院药用植物研究所,北京100094

出　　处：《Journal of Chinese Pharmaceutical Sciences》2006年第4期248-250,共3页中国药学（英文版）

摘　　要：Pueraria lobata ( Wild. ) Ohwi ( Ye-Ge in Chinese ) is a perennial herb ofthe genus Pueraria, which belongs to the Leguminosae family. It is commonly employed to relievefever and dysentery, promote the production of body fluid, reduce stiffness and pain of the nape,and for the treatment of cardiovascular diseases, e. g. hypertension, myocardial infarction, andarrhythmia. Previous phytochemical studies on P. lobata reported a number of bioactive isoflavones,e. g. daidzein, daidzin, and puerarin. Further investigation of its root has led to isolation offourteen compounds and their structures were identified as daidzein, ononin, daidzin, 3'' -methoxypuerarin, puerarin, pueroside B, daidzein-8-C-apiosyl- (1-6)-glucoside, 3''-hydroxy-puerarin,puerarinxyloside, daidzein-7, 4'' -O-glucoside, puerarin-4''-O-glucoside, mirificin-4''-O-glucoside,sissotorin, and pueroside C. Compounds 11 and 13 were isolated from the root of P. lobata for thefirst time.目的研究野葛(Pueraria lobata)根的化学成分。方法利用溶剂提取,硅胶柱色谱和凝胶色谱等手段进行分离、纯化,根据理化性质和波谱数据进行结构鉴定。结果分离鉴定了14个化合物,分别为大豆苷元(1),芒柄花苷(2),大豆苷(3), 3′-甲氧基葛根素(4),葛根素(5),葛苷B(6),大豆苷元-8-C-芹菜糖基-(1-6)-葡萄糖苷(7), 3′-羟基葛根素(8),葛根素木糖苷(9),大豆苷元-7,4′-O-二葡萄糖苷(10),葛根素-4′-O-葡萄糖苷(11),美佛辛-4′-O-葡萄糖苷(12), sissotorin(13),葛苷C(14)。结论化合物11和13为首次从野葛的根中分离得到。

关 键 词：Pueraria lobata ISOFLAVONOIDS puerarin-4′-O-glucoside sissotorin 

分 类 号：R284[医药卫生—中药学]