温氧合血连灌与冷晶体液间灌的血清cTnI变化比较  

Comparative study of plasma cardiac troponinⅠ between continous warm oxygenated blood perfusion and intermittent cold crystalloid perfusion

作　　者：冯德广[1] 庄世才[1] 张大新[1] 赵根尚[1] 法宪恩[1] 张瑞成[1] 

机构地区：[1]郑州大学第二附属医院,河南郑州450003

出　　处：《山东医药》2002年第34期9-10,共1页Shandong Medical Journal

摘　　要：为探索温血连灌的心肌保护机制,对温血连灌与冷晶体液间灌的血清肌钙蛋白I(cTnI)变化进行了对比研究,将风心瓣膜病患者20例,随机分为冷晶体液组(冷晶组)及温血组。冷晶组采用含钾冷晶体液主动脉根部间断灌注,首次剂量15ml/kg,每30分钟重复灌注一次,剂量减半。温血组采用氧合温血含钾停搏液连续灌注,开始剂量为8ml/(kg·min),心脏停搏后按0.2ml/(min·kg)持续灌注。分别于麻醉前、主动脉开放、术后6、12、24、72小时采集静脉血,用双抗体固相夹心放免法测定血清cTnI浓度。结果两组麻醉前cTnI无明显差异(P>0.05),以后各时间点冷晶组均较温血组含量增高(P<0.01)。认为温血组与冷晶组比较,能明显减轻体外循环过程中的心肌损伤,起到保护心肌的作用。To study the cardiac protection effect with the changes of plasma cardiac troponin I(cTnI) bet-ween continous warm oxygenated blood perfusion (CWOBP) and intermittent cold crystalloid perfusion (ICCP),20 patients with rheumatic heart valvular diseases undergoing valves replacement were randomized into twogroups(CWOBP group and ICCP group), 10 patients in each group. The serum samples were collected before andafter cardiopulmonary bypass. cTnI was measured by ELISA technique. Results showed that in ICCP grou...

关 键 词：心肌保护 心脏停搏液 肌钙蛋白Ⅰ 

分 类 号：R654.1[医药卫生—外科学]