GnRH-R在大鼠递增负荷训练中的表达及与性激素的关系  

Expression of GnRH R in Progressive Load Training for Rats and Its Relation with Sex Hormone

作　　者：王人卫[1] 陆爱云[1] 郭仕达[1] 高勇[1] 蔡斌[1] 段子才[1] 

机构地区：[1]上海体育学院体育保健康复系,上海200438

出　　处：《上海体育学院学报》2001年第2期26-30,共5页Journal of Shanghai University of Sport

基　　金：教育部博士点基金资助课题 ;第六届全国体育科学大会入选论文

摘　　要：:采用动物实验研究法 ,对促性腺素释放激素受体 (GnRH -R)在大鼠递增负荷训练中的表达及与性激素的关系进行分析。结果显示 ,长期大强度负荷使Ta组大鼠垂体GnRH -R表达明显低于C组 ,且同时伴有LH、E2 、P、T明显低于C组 ,FSH也低于C组 ;但是Ta组大鼠下丘脑、血浆 β -EP明显高于C组。休息 1周后GnRH -R未见恢复。认为 ,长期大强度负荷使Ta组大鼠垂体GnRH -R自身调节发生紊乱 ,是引起AMI的重要因素之一 ;过高的 β -EP抑制中枢GnRH分泌 ,是垂体GnRH -R表达减弱的主要抑制神经递质之一 ;推测AMI可能发生在下丘脑水平。By animal experiments, the present paper analyzes the expression of GnRH-R in progressive load training for rats and its relation with sex hormone. The results show that the pituitary GnRH-R of Group Ta's rats under the long-term high intensity load is obviously lower than that of Group C's rats. Meanwhile, LH, E 2, P and T of Group Ta are significantly lower than that of Group Ta. Besides this, FSH of Group Ta is also lower than Group C. However, hypothalamus, and plasma β-EP of Group Ta are evidently higher than that of Group C. After a week's rest, there is no recovery in GnRH-R of Group Ta. It is obvious that the long term high intensity load brings about self-regulation disorder in pituitary GnRH-R of Group Ta's rats under the long-term high intensity load, which is one of the important factors in leading to AMI; overhigh β-EP would restrict the secretion of GnRH, which is one of the major factors in decreasing the expression of pituitary GnRH-R; it is inferred that AMI may occur in hypothalamus level.

关 键 词：促性腺素释放激素受体 大鼠 负荷训练 下丘脑 表达强度 性激素 

分 类 号：G804[文化科学—运动人体科学] G804.7[文化科学—体育学]