经皮冠状动脉球囊成形术中反复扩张与缺血预适应现象的临床观察  

Clinical observation of ischemic preconditioning during percutaneous transluminal coronary angioplasty (PTCA) procedure

作　　者：马颖艳[1] 王述民[1] 程何祥[2] 贾国良[2] 郭文怡[2] 李伟杰[2] 

机构地区：[1]沈阳军区总医院心内科,110015 [2]西安第四军医大学西京医院心内科

出　　处：《中国介入心脏病学杂志》2001年第4期187-188,共2页Chinese Journal of Interventional Cardiology

摘　　要：目的　为探讨经皮冠状动脉腔内成形 (PTCA)术中反复多次球囊扩张阻断血流 再灌注是否能达到缺血预处理结果。方法　连续观察 97例患者PTCA术中心电图、心绞痛情况。结果　①97例患者中有 18例于首次扩张中出现室性早搏 ,再次扩张后仅有 4例仍有早搏。首次扩张检出率明显高于后者 (P <0 0 5 ) ;②首次扩张时 6 8例ST T改变的患者 ,反复扩张后仅有 2 6例仍有改变 ,而且临床心绞痛程度减轻。结论　①短暂反复的冠脉球囊扩张可减轻心肌细胞的电不稳定性 ;②首次较长时间的扩张后再灌注 。Objective To study if the ischemic preconditioning existed in the process of repetitive balloon occlusion reflow during percutaneous transluminal coronary angioplasty (PTCA) Methods The clinical and electrocardiographic responses of 97 patients undergoing PTCA were examined Results ①Ventricular premature beats took place in 18 out of 97 patients during initiall inflation versus 4 during subsequent inflation ( P <0 05) ②There were 68 patients with ST T shift during the initial inflation; whereas there were only 26 patients with ST T shift during subsequent inflation ( P <0 05) Conclusion ①Repetitive brief coronary artery inflation results in less electrical instability of myocardium; ②Repetitive brief balloon inflation reflow possesses ischemic preconditioning effect

关 键 词：血管成形术 经腔 经皮冠状动脉 预适应 缺血 

分 类 号：R54[医药卫生—心血管疾病]