胰腺移植急性排斥反应的监测  

MONITORING ACUTE REJECTION OF PANCREAS ALLOGRAFT TRANSPLANT

作　　者：李为苏[1] 罗开[1] 石群立[1] 汪义军[1] 黎介寿[1] 

机构地区：[1]南京军区南京总医院,南京210002

出　　处：《解放军医学杂志》2001年第8期581-582,共2页Medical Journal of Chinese People's Liberation Army

基　　金：全军"九五"重点课题基金项目 (编号 96 2 0 0 2 )

摘　　要：探讨如何监测胰腺十二指肠移植急性排斥反应 ,用 12头猪作同种异体胰腺十二指肠移植 ,其中 6头术后抗排斥治疗 1周。定期取胰腺组织病理检查确定有无急性排斥反应 ,定期检测胰腺淀粉酶分泌量 ,血清TNF α和一氧化氮 (NO)变化。结果显示 ,一旦发生胰腺急性排斥反应 ,淀粉酶分泌急剧下降 ,TNF α及NO则明显升高 ,与急性排斥反应发生前比较有显著差异 (P <0 .0 1)。提示胰液淀粉酶分泌量、血清TNF α和NO均可用于监测胰腺急性排斥反应 ,指导适时进行胰腺活检早期诊断。To investigate the monitoring of acute rejection of porcine pancreaticoduodenal allografts, 12 pigs were subjected to pancreaticodudenal allografts, among them 6 pigs received triple therapy for 7 days. Serial biopsies were performed in pancreas allografts for diagnosis of pancreatic acute rejection. Amylase secretion was determined periodically.The levels of TNF α and NO in serum were serially monitored.The results showed that amylase secretion decreased,TNF α and NO concentration in serum increased significantly as acute rejection was detected histo pathologically in pancreatic grafts. It suggested that monitoring of amylase secretion, serum TNF α and NO concentration could be used to decide the proper time of performing biopsy for early diagnosis of acute rejection of the pancreas allograft.

关 键 词：胰腺十二指肠移植 急性排斥反应 诊断 

分 类 号：R617[医药卫生—外科学] R657.5[医药卫生—临床医学]