衰变加速因子(DAF)与异种器官移植免疫  

Decay acceleration factor(DAF) and immunology in xenotransplantation

作　　者：叶华虎[1] 姜恒[1] 魏泓[1] 

机构地区：[1]第三军医大学动物实验中心，重庆 400038 第三军医大学应用解剖学教研室，重庆 400038 第三军医大学动物实验中心，重庆 400038

出　　处：《免疫学杂志》2001年第z1期104-107,共4页Immunological Journal

基　　金：国家 973资助项目 (G2 0 0 0 0 16 10 6 )

摘　　要：超急性排斥反应一直是异种器官移植中的主要障碍之一 ,其分子基础是补体及其激活。hDAF作为一种重要的膜结合补体调节蛋白 ,是同源限制分子。转基因技术为跨越DAF的同源限制性发挥了重要作用 ,将人DAF基因插入猪基因组 ,获得转基因猪 。Hyperaction rejection (HAR), based on the activation of complement molecules, has always been one of obstacles in xenotransplantation. Human decay acceleration factor (hDAF), as a species restricting factor and glycophosphatidylinositol(GPI) anchored protein, is a regulatory molecule of activation of complements. Transgenic technology plays an important role in overcoming the limitation of DAF. hDAF gene was integrated into pig's genome and produce transgenic pigs. In xenotransplantation, HAR was overcome effectively with organs of transgenic pigs.

关 键 词：DAF 超急性排斥反应 转基因技术 异种器官移植 

分 类 号：R392.4[医药卫生—免疫学]