脂质体携载抗HIV-1药物  

Liposomes-mediated delivery of anti-HIV agents

作　　者：郑永唐[1] 王茜[1] 戎隆富[2] 

机构地区：[1]中国科学院昆明动物研究所,云南昆明650223 [2]安徽省卫生防疫站,安徽合肥230061

出　　处：《免疫学杂志》2001年第z1期115-118,共4页Immunological Journal

基　　金：云南省中青年科学与技术学术带头人基金 (95 12 );中国科学院"西部之光"人才基金 (97);云南省自然科学基金(1999C0 0 8M);卫生部科学研究基金 (98_1_336 )资助项目

摘　　要：由于HIV耐药株的产生、特殊器官和细胞中HIV的隐匿、抗HIV药物的毒副反应及半衰期短等问题的出现 ,促使人们寻找高效低毒和具有靶向性的抗HIV药物。脂质体具有被动或主动靶向病毒复制活跃和贮存区、细胞内靶向和控制药物释放、延长药物半衰期、提高药效和降低毒副作用等优点 ,是潜在携载抗HIV药物的良好载体。Owing to rapid clearance and adverse side effects of anti HIV agents, limited ability to target HIV reservoirs in specific cells and the appearance of HIV drugs resistant strains, it is important to develop more effective, lower toxic and targeting anti HIV agents. Liposomes as drug carriers have following advantages: targeting either passively or actively viral reserviors, increasing efficacy, prolonging half life and reducing toxicity. So liposomes has shown great therapeutic potential carrier as drug delivery system for anti HIV agents. This review details the application of liposomes as drug carriers for the treatment of AIDS.

关 键 词：脂质体 HIV 抗HIV剂 药物传输系统 

分 类 号：R978.7[医药卫生—药品]