胰岛素肺部给药系统研究进展  

Research and Development of Insulin Formulations for Pulmonary Delivery System

作　　者：李肖玲[1] 安富荣[1] 陆国红[1] 

机构地区：[1]上海交通大学医学院附属仁济医院药剂科,上海200127

出　　处：《中国现代应用药学》2008年第z1期609-613,共5页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的介绍胰岛素肺部给药系统的研究进展。方法综述了肺部给药机制、胰岛素吸入制剂/装置、药动学和药效学特点、临床应用等研究内容。结果与结论胰岛素肺部给药系统的发展用以补充和/或替代皮下注射,可能是一种有效方法,使患者获得更好地糖尿病治疗结果。OBJECTIVE To introduce the research and development of insulin formulations for pulmonary delivery system.METHODS This review will discuss the mechanism of pulmonary delivery,inhaled insulin formulations/devices,pharmacokinetics and pharmacodynamics,the efficacy and safety of inhaled insulin in the treatment of diabetes. RESULTS and CONCLUSION The development of pulmonary insulin delivery to supplement and/or replace subcutaneous insulin injections may be an effective alternative,allowing patients to achieve intensive diabetes management.

关 键 词：吸入胰岛素 肺部给药 

分 类 号：R943.4[医药卫生—药剂学] R977.15[医药卫生—药学]