神香苏合滴丸中龙脑的含量测定  

Determination of Borneol in Shenxiang Suhe Dropping Pill by GC-FID

作　　者：张莲珠[1] 吕雪峰[1] 刘丽健[1] 赵全成[1] 

机构地区：[1]吉林天药科技有限公司,长春130012

出　　处：《中国现代应用药学》2008年第z1期633-635,共3页Chinese Journal of Modern Applied Pharmacy

基　　金：吉林省科技厅科技发展计划资助项目(编号:20050921)

摘　　要：目的 建立神香苏合滴丸中龙脑的含量测定方法.方法 采用气相色谱法,以萘为内标物,色谱柱:石英毛细管柱(30 m×0.25 mm ×0.25 μm),(HP-INNOWAX)INNO相(TM)键合聚乙二醇;氢气: 40 mL·min-1,空气:400 mL·min-1,载气:氦气;程序升温: 130～150 ℃(8 ℃·min-1),150～205 ℃(20 ℃·min-1),205～240 ℃(15 ℃·min-1,10 min),检测器:250 ℃;柱流量:1 mL·min-1.结果 分离效果较好,对照品浓度和内标物浓度比值在0.303～1.515 内呈良好线性关系,平均回收率为96.93%.结论 本文所建立的方法用于神香苏合滴丸中龙脑的含量测定,准确可行.OBJECTIVE To establish a method for the determination of borneol in Shenxiang Suhe Dropping Pill.METHODS Naphthalene was used as internal standard and detected by capillary gas chromatography.The column temperature was 130~150 ℃(8 ℃·min-1),150~205 ℃(20 ℃·min-1),205~240 ℃(15 ℃·min-1,10 min),the detector temperature was 250 ℃. RESULTS The average recovery rate was 96.93%(n=5).CONCLUSION The method is accurate and can be applied in the determination of the preparation.

关 键 词：气相色谱 神香苏合滴丸 龙脑 含量测定 

分 类 号：R917.101[医药卫生—药物分析学] R927.2[医药卫生—药学]