注射用呋苄西林钠与甲硝唑磷酸二钠的配伍稳定性考察  

Compatible Stability of Furbenicillin sodium for Injection with Metronidazole Disodium Phosphate

作　　者：杜利萍[1] 

机构地区：[1]浙江医院,杭州310007

出　　处：《中国现代应用药学》2008年第z2期729-731,共3页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的考察注射用呋苄西林钠与甲硝唑磷酸二钠在氯化钠注射液中的配伍稳定性。方法在室温条件下(20℃),采用紫外双波长分光光度法分别测定呋苄西林钠与甲硝唑磷酸二钠配伍8 h内的含量,并比较配伍前、后其外观、pH值的变化。结果配伍后呋苄西林钠与甲硝唑磷酸二钠的含量、pH值及外观均无明显变化。结论注射用呋苄西林钠与甲硝唑磷酸二钠可加入氯化钠注射液中的配伍应用,在室温条件下,应在8 h内使用。OBJECTIVE To study the compatible stability of furbenicillin sodium for injection with metronidazole disodium phosphate in sodium chloride injection.METHODS The contents of 2 constituents of the mixed solution stored at 20 ℃ within 8 h was determined by dual ultraviolet wavelength spectrophotometry,and the appearance,pH value of the mixture were compared with those before. RESULTS No significant change was found after mixing.CONCLUSION Furbenicillin sodium for injection is compatible with metronidazole disodium phosphate in sodium chloride injection within 8 h.

关 键 词：紫外分光光度法 呋苄西林钠 甲硝唑磷酸二钠 配伍 稳定性 

分 类 号：R969.2[医药卫生—药理学] R978.11[医药卫生—药学]