2型糖尿病合并非酒精性脂肪肝临床资料分析  

Analysis of clinical data on nonalcoholic fatty liver disease in patients with type 2 diabetes

作　　者：梁晓刚[1] 周涛[1] 高继东[2] 

机构地区：[1]青海大学医学院,青海西宁810001 [2]青海大学附属医院内分泌科,青海西宁810001

出　　处：《中国医疗前沿（学术版）》2008年第6期34-35,共2页China Healthcare Innovation

摘　　要：目的探讨2型糖尿病合并非酒精性脂肪肝的危险因素。方法2型糖尿病合并非酒精性脂肪肝(DFL)组93例,2型糖尿病无非酒精性脂肪肝(NDFL)组90例,用空腹C肽代替胰岛素改良HOMA公式评价胰岛素抵抗。结果DFL组体质量指数、腰围、空腹C-肽、餐后2小时C-肽、丙氨酸氨基转移酶、天冬氨酸氨基转移酶、谷氨酰胺转移酶、总胆固醇、三酰甘油、高密度脂蛋白、低密度脂蛋白、血尿酸和HOMA(CP)升高(均P<0.05);Logistic回归分析表明体重指数、高甘油三酯血症、空腹C-肽是DFL形成的危险因素。结论2型糖尿病合并非酒精性脂肪肝的危险因素是肥胖、高甘油三酯血症和胰岛素抵抗。Objective Toinvestigate risk factors ofnonalcoholic fattyliver disease in patients with type 2 diabetes. Methods The investigation was conducted by means of case control study,including 93 patients of type 2 diabetes with fatty liver (DFL), 90 type 2 diabetes without fatty liver (NDFL). Fasting C-peptide to replace insulin in homeostasismodel assessment (HOMA) was applied to assess the status of insulin resistance. Results Patients with fatty liver in type 2 diabetes had markedly higher body mass index,waist circumference, fasting C- peptide , 2hC- peptide, alanine aminotransferase, aspartate aminotransferase, transglut- aminase,triglycende,total cholesterol,high density lipoprotein,lowdensity lipoprotein, lithic acid and HOMA (CP) than those in controls (P < 0.05 for all). Logistic regression analysis showed that BMI, hypertriglycende and fasting C-peptide were themain risk factors for nonalcoholic fatty liver disease in patients with type 2 diabetes. Conclusion The themain risk factors for nonalcoholic fattyliver disease in patients with type 2 diabetes are obesity, hypertriglycende and insulin resistance.

关 键 词：2型糖尿病 非酒精性脂肪肝 胰岛素抵抗 

分 类 号：R587.1[医药卫生—内分泌]