趋化因子对调节性NK细胞归巢的诱导作用  

Induction effect of cytokines in the homing function of regulatory NK cells

作　　者：王慧琪[1] 李萃[2] 林羿[1] 王文静[1] 曾山[1] 

机构地区：[1]暨南大学组织移植与免疫研究中心,广州510632 [2]中南大学湘雅医院卫生部肿瘤蛋白质组学重点实验室,长沙410008

出　　处：《现代免疫学》2008年第6期457-464,共8页Current Immunology

基　　金：国家自然科学基金资助项目(30730087、30672231、30500558);新世纪优秀人才支持计划项目(200770)

摘　　要：调节性T细胞和调节性NK细胞都可能在维持妊娠方面发挥关键作用。研究显示,同种异基因妊娠非肥胖型糖尿病(NOD)小鼠胚胎丢失率显著增高,而注射抗唾液酸神经节苷脂清除其残存的NK细胞,可使胚胎丢失率进一步增高。相反,过继性输注来源于正常小鼠的CD49b+CD25+NK细胞可显著降低胚胎丢失率。检测了CXCL12的特异性受体CXCR4在NK细胞表面的表达模式,并采用体外和体内迁移实验研究了NK细胞的迁移规律。由于以往研究证实小鼠胎盘滋养层细胞表达CXCL12,研究结果提示:孕期动员子宫外表达CXCR4的CD49b+CD25+NK细胞向妊娠子宫内迁移,可能对于调节母胎免疫耐受具有重要意义。The regulatory T cells as well as the regulatory NK cells may play essential roles in the maintenance of normal pregnancy.In the present study,a significantly high percentage of spontaneous embryo loss was observed in allogeneic non-obese diabetic mice(NOD) and the percentage was further increased by the administration of anti-asialo ganglio-N-tetraosylceramide(ASGM1) to deplete NK cells,but it was decreased by adoptive transfer of CD49b+CD25+ NK cells from normal mice.The expression pattern of CXCR4(specif...

关 键 词：动物模型 细胞迁移 免疫调节 妊娠耐受 

分 类 号：R392.12[医药卫生—免疫学]