高压氧治疗新生儿缺氧缺血性脑病的疗效及其对血清白介素-6和一氧化氮的影响  

Curative Effects of Hyperbaric Oxygen Therapy on Hypoxic-ischemic Encephalopathy and Its Influence on Serum Interleukin-6 and Nitric Oxide

作　　者：王慧 王立金[2] 

机构地区：[1]新华医疗集团新华医院儿科,安徽省淮南市232052 [2]安徽理工大学医学院病理生理教研室

出　　处：《中国全科医学》2008年第24期2213-2214,共2页Chinese General Practice

摘　　要：目的探讨高压氧(HBO)治疗新生儿缺氧缺血性脑病(HIE)的疗效及其对血清白介素-6(IL-6)和一氧化氮(NO)的影响。方法将60例HIE患儿随机分为常规治疗组和HBO治疗组,比较两组的疗效;另选择10例正常新生儿为对照组,对3组新生儿的血清IL-6和NO水平进行测定并比较。结果HBO治疗组和常规治疗组患儿的临床疗效间差异有统计学意义(P<0.05);治疗前常规治疗组、HBO治疗组的IL-6和NO水平与对照组间差异均有统计学意义(P<0.01);HBO治疗组治疗前后IL-6的差值、NO的差值与常规治疗组治疗前后的差值比较,差异均有统计学意义(P<0.05)。结论HBO治疗HIE有较好疗效;HBO治疗HIE可能是通过降低IL-6和NO水平而减轻脑细胞损害的。Objective To study the effect of hyperbaric oxygen therapy(HBOT) on serum IL-6 and Nitric Oxide(NO) in newborns with hypoxic-ischemic encephalopathy(HIE).Methods Sixty HIE patients were randomly divided into HBO group and routine-treatment,and10 normal newborns served as control.Serum IL-6 and NO levels were determined before and after HBOT.Results There was significant difference in curative effect between HBO and routine-treatment groups(P<0.05);A significant decrease in serum IL-6 and NO was demonstra...

关 键 词：高压氧 缺氧缺血 脑 白介素-6 一氧化氮 婴儿 新生 

分 类 号：R459.6[医药卫生—治疗学]