肿瘤相关抗原CT45的HLA-A2/A3限制性CTL表位的预测  

Prediction of the HLA-A2/A3-restricted CTL epitopes derived from the tumor associated antigen CT45

作　　者：高艳锋[1] 翟明霞[1] 祁峰[1] 陈鲤翔[1] 祁元明[1] 

机构地区：[1]郑州大学生物工程系,河南郑州450001

出　　处：《现代肿瘤医学》2008年第11期1850-1852,共3页Journal of Modern Oncology

基　　金：河南省科技攻关资助项目(0624410024);河南省医学科技攻关计划资助项目(2006003)

摘　　要：目的:预测肿瘤相关抗原CT45的HLA-A2/A3限制性CTL表位,为CTL表位肽的合成和活性筛选提供依据。方法:基于新近发现的CT45抗原的氨基酸序列,用NetCTL 1.2 Server人工神经网络法远程预测系统进行HLA-A2/A3限制性CTL表位预测打分,挑选出分值较高的作为候选表位。结果:共预测出了5个潜在的HLA-A2限制性CTL表位九肽,15个潜在的HLA-A3限制性CTL表位九肽,所有这些表位均为首次报道。结论:NetCTL 1.2 Server人工神经网络法能高效的预测CTL表位肽,基于新近发现的CT45抗原,我们通过该系统成功预测出了5个潜在的HLA-A2限制性CTL表位,15个潜在的HLA-A3限制性CTL表位,可以对其进行进一步的研究。Objective:To predict the HLA-A2/A3-restricted cytotoxic T lymphocyte(CTL) epitopes of tumor antigen CT45 so as to provide appropriate CTL epitope for tumor immunotherapy.Methods: The HLA-A2/A3-restricted CTL epitopes of tumor antigen CT45 were predicted by artificial neural networks method on NetCTL 1.2 Server.Peptides with higher scores were selected as candidate epitopes.Results:Five HLA-A2-and fifteen HLA-A3-restricted CTL epitopes derived from the tumor antigen CT45 were predicted.All these peptides hav...

关 键 词：抗原肽 肿瘤 CT45 表位预测 

分 类 号：R392[医药卫生—免疫学]