糖尿病周围神经病变危险因素分析  

Analysis on risk factors for diabetic peripheral neuropathy

作　　者：张进[1] 薛波[1] 施弘[1] 钱雪梅[2] 刘芳[3] 

机构地区：[1]上海交通大学附属第六人民医院神经内科,200233 [2]上海交通大学附属第六人民医院脑电功能室,200233 [3]上海交通大学附属第六人民医院内分泌代谢科,200233

出　　处：《上海医学》2008年第10期721-723,共3页Shanghai Medical Journal

摘　　要：目的探讨糖尿病周围神经病变(DPN)的相关危险因素。方法收集254例2型糖尿病患者的年龄、体质指数、腰臀比、糖尿病病程、血压、空腹血糖、餐后2h血糖、糖化血红蛋白、血脂、胰岛B细胞功能等临床资料。根据神经传导速度(NCV)将患者分为DPN组(144例)和非DPN组(110例)。对有统计学意义的危险因素行多因素Logistic回归分析,筛选DPN的危险因素。结果DPN组的年龄、糖尿病病程、收缩压、糖化血红蛋白水平均显著高于非DPN组(P值均<0.01)。多因素Logistic回归分析提示,年龄(OR=1.051,95%CI为1.018~1.085,P=0.002)、糖尿病病程(OR=1.059,95%CI为1.008~1.113,P=0.022)和糖化血红蛋白(OR=1.183,95%CI为1.060~1.319,P=0.003)是DPN的危险因素。结论DPN的发生与患者的年龄、糖尿病病程和糖化血红蛋白增高有关,代谢因素在其发病机制中起重要作用,是DPN的独立危险因素。Objective To study the risk factors for diabetic peripheral neuropathy (DPN). Methods The clinical data of 254 patients with type 2 diabetes, including the age, body mass index (BMI), waist/hip radio (WHR), course of diabetes, blood pressure, fasting plasma glucose (FPG), 2 h postprandial plasma glucose (2 hPG), HbA1c, lipid and islet B cell function were collected. The patients were divided into 2 groups according to the nerve conduction velocity (NCV): DPN group (144 cases) and non-DPN group (110 cases). ...

关 键 词：糖尿病周围神经病变 危险因素 糖化血红蛋白 

分 类 号：R587.2[医药卫生—内分泌]