痹清胶囊对大鼠急性痛风性关节炎白细胞介素12及诱导型环氧化酶表达的影响  

Influence of Biqing Capsule on IL-12 and COX-2 Expression in Mouse with Acute Gouty Arthritis

作　　者：周敏[1] 董娜[1] 韩玉生[1] 万丽鹤[1] 杨伟鹏[2] 

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]中国中医科学院中药研究所,北京100700

出　　处：《中国实验方剂学杂志》2008年第11期53-55,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：黑龙江自然科学基金项目(D0318)

摘　　要：目的:采用尿酸钠(MUS)诱导的大鼠急性痛风性关节炎模型,研究痹清胶囊治疗急性痛风性关节炎作用机理。方法:采用ELISA方法测定踝关节液白细胞介素12(IL-12)的含量及采用免疫组化方法测定大鼠踝关节诱导型环氧化酶(COX-2)的表达。结果:痹清胶囊明显降低痛风性关节炎模型大鼠踝关节IL-12的含量、抑制大鼠踝关节COX-2的表达。结论:痹清胶囊治疗痛风性关节炎有确切疗效,可能与降低IL-12的含量、抑制COX-2的表达有关。Objective:By uric acid sodium(MUS)-induced acute gouty arthritis model,to observe Biqing Capsule treatment for acute gouty arthritis.Methods: The IL-12 content in joint fluid of ankle was measured by ELISA method.Mouse ankle COX-2 expression was determined by immunohistochemical methods.Results:Biqing Capsule obviously decreased ankle IL-12 levels and restrained rat ankle COX-2 expression.It indicated that Biqing Capsule for acute gouty arthritis had some anti-inflammatory effects.Conclusion: The Biqing Cap...

关 键 词：痹清胶囊 尿酸钠 痛风性关节炎 白细胞介素12 诱导型环氧化酶 

分 类 号：R285.5[医药卫生—中药学]