不同吸氧流量对急性心肌梗死缺氧性损伤的作用研究  

Study of different oxygen inhalation on myocardial injury in acute myocardial infarction(AMI) rabbits

作　　者：潘显芳[1] 

机构地区：[1]浙江省台州学院医学院,浙江台州318000

出　　处：《中国现代医学杂志》2008年第21期3120-3122,共3页China Journal of Modern Medicine

摘　　要：目的比较不同吸氧流量减轻急性心肌梗死(acute myocardial infarction,AMI)缺氧性损伤的效果。方法在40只家兔AMI动物模型中,经气管插管吸入氧气,比较0,0.8,1.2和1.8L/min4种吸氧流量对A-MI的作用。吸氧效应指标以动脉血氧分压(PaO2)和氧饱和度(SaO2)表示;心肌损伤指标有心电图,心肌酶和心脏病理学检查。结果动物形成AMI模型后PaO2和SaO2下降;心肌损伤程度与PaO2和SaO2降低有关;吸氧能增加AMI动物PaO2和SaO2水平;SaO2≥95%的AMI动物心肌损伤程度较轻。结论根据AMI缺氧具体情况选择吸氧流量,确保SaO2≥95%有助于减轻心肌损伤。Objective To investigate the effect of oxygen inhalation on reducing myocardial injury in the acute myocardial infarction(AMI) rabbits.MethodsAn animal model of AMI was created in 40 rabbits by ligation of the left anterior descending coronary artery(LAD).The results of arterial blood oxygen saturation(SaO2) and pressure(PaO2), electrocardiograme, myocardial enzyme and pathological changes were evaluated after oxygen inhalation in flow of 0, 0.8, 1.2 and 1.8 liter/min.ResultsSaO2 and PaO2 were descended app...

关 键 词：氧吸入疗法 血气分析 心肌梗死 

分 类 号：R542.22[医药卫生—心血管疾病]