丹红注射液对酒精性肝损伤的保护作用  

Protective function of Danhong injection on alcoholic liver damage

作　　者：闫爱春[1] 葛丽平[1] 薄爱华[1] 张晓丽[1] 芦广萍[1] 

机构地区：[1]河北北方学院,河北张家口075000

出　　处：《中国现代医学杂志》2008年第21期3139-3141,3148,共4页China Journal of Modern Medicine

基　　金：河北省科学技术研究与发展指导计划项目(No:072761580)

摘　　要：目的观察丹红注射液对酒精性肝病的保护作用。方法利用20%酒精喂养法复制酒精性肝病动物模型,然后采用丹红注射液进行治疗。与正常对照组和模型对照组比较,在光、电镜下观察肝脏结构变化,检测血清中SOD和MDA的变化。结果丹红治疗组肝细胞脂滴减少,线粒体、内质网和核糖体增多,间质炎性细胞和贮脂细胞减少,SOD活性明显升高,MDA含量显著下降,与模型组比较差异有显著性(P<0.05)。结论丹红注射液对酒精性肝病有明显的治疗作用。Objective To investigate the protective function of Danhong injection to liver disease caused by alcohol.MethodsThe model of alcoholic liver disease in animals bred with 20% alcohol and Compared the result with control groups.The changes of liver structure, SOD and MDA in serum were observed under the light and electron microscope.ResultsThe fat drops of liver cells in Danhong injection group reduced, while mitochondria, endoplasmia reticulum and ribosome increased.Not only did interstitical inflammatory ce...

关 键 词：酒精性肝病 丹红注射液 肝脏 超微结构 

分 类 号：R285.5[医药卫生—中药学]