酮康唑对泮托拉唑在大鼠体内的药动学的影响  

Effects of Ketoconazole on the pharmacokinetics of Pantoprazole in Wistar rats

作　　者：李沙莎[1] 尹桃[1] 秦群[1] 

机构地区：[1]中南大学湘雅医院药剂科,湖南长沙410008

出　　处：《中国现代医学杂志》2008年第21期3107-3109,共3页China Journal of Modern Medicine

摘　　要：目的研究酮康唑对泮托拉唑在大鼠体内药动学的影响,为临床合理用药提供参考。方法12只大鼠随机分为实验组和对照组,灌胃给予泮托拉唑,实验组于给药前2h腹腔注射酮康唑,以高效液相色谱法测定泮托拉唑血药浓度,采用DAS软件计算药动学参数,以SPSS软件对组间各参数进行统计分析。结果两组达峰时间和峰浓度相似(P>0.05),实验组的半衰期T1/2和曲线下面积AUC0→∞明显大于对照组(P<0.05),表观清除率CL/F则明显小于对照组(P<0.05)。结论肝药酶抑制药酮康唑可减弱大鼠对泮托拉唑代谢能力。Objective The purpose of this study was to investigate the effects of Ketoconazole to the pharmacokinetics of Pantoprazole in Wistar rats.Methods12 Wistar rats all received 20 mg/kg Pantoprazolealone(control group) or in combination with 50 mg/kg Ketoconazole(test group).The plasma concentration of Pantoprazole was determined by HPLC and the pharmacokinetics parameters were calculated with DAS software.Statistical analysis was performed with SPSS software.ResultsT1/2 and AUC0→∞ of Pantoprazole in test rats ...

关 键 词：泮托拉唑 酮康唑 药动学 

分 类 号：R969.1[医药卫生—药理学]