多重耐药鲍曼不动杆菌的耐药性和同源性研究  

Mulfidrug resistance of acinetobacter baumanii and homogeneous analysis

作　　者：谢妮[1] 高霞[1] 张洪[1] 

机构地区：[1]南方医科大学附属深圳医院深圳市第二人民医院,广东深圳518035

出　　处：《中国现代医学杂志》2008年第22期3345-3348,共4页China Journal of Modern Medicine

基　　金：广东省深圳市科技计划项目医疗卫生类基金资助项目(No:200702116)

摘　　要：目的了解重症监护病房(ICU)的多重耐药鲍曼不动杆菌的耐药谱特征及其同源性,为临床防治和控制院内感染提供依据。方法收集该院重症监护病房2007年3～9月分离出的14株鲍曼不动杆菌,采用E-test法测定15种抗菌药物的最低抑菌浓度(MIC)并采用随机扩增多态性DNA(RAPD)技术分析其耐药株的同源性。结果14株菌对头孢菌素类,氨基甙类和氟喹若酮类等抗菌素均显示出较高水平的多重耐药性;RAPD分型11株菌有高度同源性。结论分离自ICU的鲍曼不动杆菌多重耐药率较高,且大多数菌株有高度同源性。【Objective】To understand the drug-resistant status of Acinetobacter baumanii isolated from ICU and provide scientific basis for treatment of infection and control hospital onset of infection.【Methods】Collected 14 strains Acinetobacter baumannii from Mar.2007 to Sep.2007 in ICU of our hospita1,the minimum inhibitory concen-trations (MIC) were examined by E-test.The homology of the resistance isolates was examined by randomly ampli-fied polymbrphic DNA technique (RAPD).【Results】Fourteen multiresistance-resist...

关 键 词：鲍曼不动杆菌 多重耐药 基因分型 随机扩增多态性DNA技术 

分 类 号：R446.5[医药卫生—诊断学]