动态血压监测比较贝尼地平片与硝苯地平控释片的临床疗效  

Comparison of Benidipine to Nifediping controlled released tablets in the treatment of hypertension by ambulatory blood pressure monitoring

作　　者：罗新林[1] 衣为民[1] 赵敏[2] 

机构地区：[1]广东深圳市孙逸仙心血管医院,广东深圳518020 [2]中南大学湘雅医院,湖南长沙410078

出　　处：《中国现代医学杂志》2008年第22期3365-3368,共4页China Journal of Modern Medicine

摘　　要：目的应用动态血压监测(ABPM)的方法,评价盐酸贝尼地平和硝苯地平控释片对轻、中度高血压病的疗效。方法选择原发性高血压患者118例随机分为盐酸贝尼地平组(n=56)和硝苯地平控释片组(n=62),分别给与盐酸贝尼地平、硝苯地平控释片治疗,疗程为8周,并于治疗前后进行动态血压监测(ABPM)。结果两药均能降低24h、白昼、夜间血压,但差异无统计学意义,仅硝苯地平控释片全日平均收缩压下降有统计学差异(P<0.05)。硝苯地平控释片组服药后24h舒张压的平滑指数(24hSID)、白天收缩压的平滑指数(dSIS)、夜间舒张压的平滑指数(nSID)较服药前有明显降低(P<0.05),贝尼地平组服药后24hSID、nSID较服药前有明显降低(P<0.05),同时硝苯地平控释片组服药后24h收缩压的平滑指数(24SID)、夜间收缩压的平滑指数(nSID)均较贝尼地平组明显降低(P<0.01)。硝苯地平控释片组、贝尼地平组的收缩压晨峰服药后均较服药前减低(P<0.05),硝苯地平控释片组舒张压晨峰服药后较服药前减低(P<0.05),但两组间比较,差异无显著性。两药均无明显不良反应发生。结论盐酸贝尼地平和硝苯地平控释片一样的能安全有效的降压。两者均能有效控制晨峰,具有满意的平滑指数。【Objective】To assess the antihypertensionsive effect of Benidipine and Nifediping controlled released tablet in patients with essential hypertension by ambulatory blood pressure monitoring (ABPM).【Methods】118 pa-tients with essential hypertension were enrolled and arranged randomly to two groups.They were treated with Beni-dipine (n =56) or Nifediping controlled released tablets (n =62) respectively for 8 weeks and visited every two weeks.ABPM and biochemical examination were performed before and after drug...

关 键 词：贝尼地平 硝苯地平控释片 高血压 晨峰 动态血压监测 

分 类 号：R544.1[医药卫生—心血管疾病]