子宫内膜异位症中环氧合酶-2阳性反应细胞的定量研究  

Quantitative study of cyclooxygenase-2 positive cells in endometriosis

作　　者：张晓玲[1] 王爽[2] 朱清仙[2] 

机构地区：[1]江西省妇幼保健院妇科,南昌330006 [2]南昌大学医学院,南昌330006

出　　处：《中国体视学与图像分析》2008年第3期177-179,共3页Chinese Journal of Stereology and Image Analysis

摘　　要：目的探讨环氧合酶-2(COX-2)与子宫内膜异位症(Ems)发病的相关性。方法采用免疫组织化学和体视学方法检测40例Ems患者和20例非Ems患者在位内膜和异位内膜中COX-2的含量。结果COX-2在所有子宫内膜的腺细胞和间质细胞中均有表达;COX-2阳性反应细胞的体密度和数密度在Ems患者在位内膜及异位内膜中均明显高于非Ems子宫内膜(P<0.01);Ems患者异位内膜中COX-2阳性反应细胞的体密度和数密度都高于在位内膜(P<0.05)。结论COX-2在Ems发病中起着重要作用。Objective To explore the function of cyclooxygenase-2 (COX-2) in pathogenesis of endometriosis (Ems). Methods Immunohistochemical and morphometric techniques were used to make a quantitative analysis of COX-2 positive cells in 40 Ems cases in comparison with 20 women without Ems. Results Immunoreactivity of COX-2 was found in epithelial and stromal cells in uterine endometrium. The volume density and numerical density of COX-2 positive cells in uterine endometrium of Ems were significantly higher than that ...

关 键 词：子宫内膜异位症 环氧合酶-2阳性反应细胞 子宫内膜 免疫组织化学 定量形态学 

分 类 号：R711.71[医药卫生—妇产科学]