黄芩苷元对大鼠心肌缺血再灌注损伤的保护作用  

Protection effect of baicalein on myocardial ischemia-reperfusion injury in rats

作　　者：黄贤华[1] 贺方兴[2] 郑建锋[1] 刘贤伟[1] 黄常亮[1] 杨芳炬[3] 

机构地区：[1]赣南医学院药理教研室,赣州341000 [2]赣南医学院病理教研室,赣州341000 [3]四川大学华西医学中心药理教研室,成都610041

出　　处：《中药药理与临床》2008年第5期20-22,共3页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家重点基础研究发展计划(2007CB512604)

摘　　要：目的:观察黄芩苷元(Baicalein,Bai)对大鼠心肌缺血再灌注损伤的保护作用及其机制。方法:结扎大鼠左冠状动脉前降支以制备心肌缺血再灌注损伤模型,比色法检测大鼠血清中超氧化物歧化酶(SOD)、丙二醛(MDA)、髓过氧化物酶(MPO)、乳酸脱氢酶(LDH)水平和心肌中LDH、肌酸激酶(CK)含量;放射免疫法测血浆中内皮素(ET)和心钠素(ANP)的含量。结果:与模型组比,Bai能降低血清中LDH、MDA、MPO含量,提高血清中SOD活性;降低血浆中ET含量,提高血浆中ANP水平;增加心肌中LDH、CK含量。结论:Bai对心肌缺血再灌注损伤有保护作用,作用机制可能与其抗氧化、减少心肌酶的漏出等作用有关。Objective: To investigate protection effect of baicalein on myocardial ischemia-reperfusion injury in rats.Methods: The myocardial ischemia-reperfusion injury model in rats were established by ligating left anterior descending coronary artery.Content of lactate dehydrogenase(LDH),superoxide dismutase(SOD),malondialdehyde(MDA),myeloperoxi-dase(MPO) in serum and LDH,creatine kinase(CK) in myocardium were measured by chromatometry;Content of endothelin(ET) and atrial natriuretic peptide(ANP) were measured in p...

关 键 词：黄芩苷元 心肌缺血 再灌注损伤 

分 类 号：R285[医药卫生—中药学]