正清风痛宁肠溶片在犬体内的药动学及绝对生物利用度研究  

Pharmacokinetics and absolute bioavailability of Zhengqing Fengtongning Enteric Tablets(正清风痛宁肠溶片) in Beagle dogs

作　　者：王柯静[1] 周远大[1] 何海霞[1] 冯晓科[2] 康纪平 李秋波[2] 

机构地区：[1]重庆医科大学附属第一医院临床药理研究室,重庆400016 [2]四川都江堰养麝研究所,都江堰611830

出　　处：《中药药理与临床》2008年第6期17-19,共3页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：目的:研究了正清风痛宁肠溶片在犬体内的药代动力学及绝对生物利用度。方法:采用双周期自身交叉设计,10只Beagle犬分别静脉及口服给予正清风痛宁肠溶片10mg/kg,HPLC法测定血浆中的药物浓度,3p97软件计算二者药动学参数和绝对生物利用度。结果:犬静注给予青藤碱后,药-时曲线呈二室模型,T1/2β为106.67±12.2min,AUC0~t为(93.32±8.07)μg/min·ml。犬口服正清风痛宁肠溶片后,药-时曲线为一室模型,T1/2(Ka)为(36.0±7.97)min,T1/2(Ke)为(84.77±19.33)min,Tmax为(79.27±15.62)min,Cmax为(0.18±0.049)μg/ml,AUC0~t为(38.51±13.23)μg/min·ml。口服青藤碱的绝对生物利用度为41.26%。结论:正清风痛宁肠溶片生物利用度较高,在临床能产生较好的疗效。Objective:To investigate the pharmacokinetic characteristics of Zhengqing Fengtongning enteric tablets and its absolute bioavailability in Beagle dogs.Method:According to a randomized two-period crossover design,ten Beagle dogs were administrated by iv or po 100mg sinomenine respectively with a 7-day washout,whose plasma sinomenine level was measured by HPLC.The pharmacokinetic parameters and bioavailability of enteric tablets were calculated by 3p97 software.Result:The pharmacokinetics behavior of sinomeni...

关 键 词：青藤碱 正清风痛宁肠溶片 药动学 绝对生物利用度 

分 类 号：R285[医药卫生—中药学]