果糖二磷酸锶改善糖尿病大鼠睾丸病变及对前原内皮素和内皮素转变酶表达的影响  

Effects of strontium fructose 1,6-diphosphate (FDP-Sr) on didymus lesion and the mRNA expressions of prepro ET-1(PPET-1)and endothelin converting enzyme (ECE) in diabetic rats

作　　者：张琪[1] 汤晓赟[2] 戴德哉[2] 应汉杰[1] 戴茵[2] 

机构地区：[1]南京工业大学制药与生命科学学院 [2]中国药科大学药理研究室

出　　处：《中国临床药理学与治疗学》2008年第12期1339-1343,共5页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金项目(30572217)

摘　　要：目的:研究果糖二磷酸锶(FDP-Sr)对糖尿病睾丸病变的改善,与丙酸睾酮对比,并初步探讨其可能机制。方法:链脲佐菌素致糖尿病雄性大鼠8周,在后4周,分别每日灌胃FDP-Sr(50,100,200mg/kg)以及丙酸睾酮(4mg/kg,s.c.治疗),测血中睾酮、谷胱甘肽过氧物酶(GSHpx)、睾丸中内皮素-1(ET-1)系统中前原ET-1(前原内皮素,ppET-1)和ET转变酶(ECE)的mRNA表达,观察睾丸组织学改变。结果:糖尿病大鼠睾丸曲细精管萎缩明显,血中睾酮、GSHpx明显降低,ppET-1和ECE呈高表达。上述改变被FDP-Sr明显改善,丙酸睾酮作用不明显。结论:FDP-Sr治疗糖尿病睾丸病变优于丙酸睾酮,可能与抑制睾丸中内皮素系统的高表达相关。AIM:To determine the benefits of FDP-Sr on streptozotocin(STZ)induced diabetic testopathy in rats,compared with testosterone propionate,and explore its likely mechanisms.METHODS:Male SD rats were given streptozotocin to induce strontium fructose 1,6-diphosphate(EDP-sr)diabetes for 8 weeks and in the second 4 weeks rats were treated with FDP-Sr(50,100,200 mg/kg,i.g.)and testosterone propionate(4 mg/kg,s.c.).GSH-px,mRNA expression of perpro ET-1(ppET-1),endothelin coverting enzyme(ECE)in testicular tissues,mo...

关 键 词：糖尿病 睾丸病 内皮素 果糖二磷酸锶 睾酮 替代治疗 

分 类 号：R587.1[医药卫生—内分泌]