小鼠实验性肺气肿研究若干进展  

Development of mice experimental emphysema

作　　者：钱伯初[1] 史红[1] 郑晓亮[1] 

机构地区：[1]浙江省医学科学院药物研究所

出　　处：《中国临床药理学与治疗学》2008年第9期1076-1080,共5页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：肺气肿是一种终末气腔不可逆扩张和破坏的严重呼吸系统病变,临床和基础研究进展缓慢。近年来虽提出各种各样动物模型,但具实用价值者仍极有限。复制肺气肿动物模型有周期长,个体差异大,肺功能测定困难及可靠性差等问题。本文简要介绍小鼠实验性肺气肿研究若干进展,包括应用不规则碎片形几何学方法测量小鼠肺气肿形态学变化、烟熏诱发肺气肿模型的小鼠易感品系及CD8+T、B淋巴细胞与肺气肿发病机理等研究内容,为小鼠肺气肿模型提供新思路。Emphysema is one of serious disease in respiratory system that consists of irreversible dilatation and destruction of terminal airspaces of the lung,and the development of clinic and basic study are slowness.In recent years,different animal models of pulmonary emphysema were described in some species such as mice,rats,rabbits,dogs and sheep.But their practicality are still limited because of the long periods of preparation,larger difference of individual,difficult measure and uncertain dependability of pulm...

关 键 词：肺气肿 动物模型 吸烟 T细胞 B细胞 小鼠 

分 类 号：R563.3[医药卫生—呼吸系统]