布比卡因抑制大鼠热痛过敏行为的实验观察  

Lab research of bupivacaine inhibiting hyperalgesia

作　　者：唐锡萍[1] 谢益宽[1] 井艳玲[1] 

机构地区：[1]广州医学院病理教研室

出　　处：《中国中医药现代远程教育》2008年第10期1160-1161,共2页Chinese Medicine Modern Distance Education of China

摘　　要：目的研究神经损伤即刻给予布比卡因对热痛过敏症状产生的抑制作用。方法将CCI(慢性压迫性损伤)模型大鼠随机分为对照组和实验组。实验组在坐骨神经轻度结扎后即刻于神经损伤区周围包埋布比卡因粉剂或胶溶剂,而对照组不给药。观察两组大鼠在行为学和电生理学上的差异。结果①行为学测定:实验组大鼠始终未出现热痛过敏症状,而对照组大鼠出现了持续的热痛过敏症状。②电生理实验:实验组大鼠坐骨神经中枢端的神经纤维自发放电百分数显著低于对照组。结论神经损伤后即刻在损伤区给予布比卡因可有效预防热痛过敏症状的产生。Objectives To compare bupivacaine-treated group in which the CCI rats were treated with bupivacaine immediately following the sciatic nerve injury so as to block ectopic discharge elicited by the injuried nerve to control group, activities of two aspects are tested: behaviour measurement and elctrophysiological records. Methods (1)behaviour measurement: measure the time course of hyperalgesia by the noxious heat-evoked withdrawal reflex. (2)electrophysiology records: Single unit recording technique was adop...

关 键 词：慢性痛 异位电活动 热痛过敏 布比卡因 中医实验医学 

分 类 号：R96[医药卫生—药理学]