相同日剂量加替沙星单次与分2次治疗呼吸及泌尿系细菌感染临床疗效比较  

Comparision of efficacy of same daily dose of gatifloxacin for urinary system and respiratory system Bacterial infection in single dose vs.in 2divided dodes

作　　者：周蔚然[1] 李柏完[1] 杨扬 

机构地区：[1]南华大学附属第三医院,湖南衡阳421900

出　　处：《中国医疗前沿》2008年第6期106-108,共3页China Healthcare Innovation

摘　　要：目的观察加替沙星日单次给药治疗呼吸及泌尿系细菌感染的临床疗效,并与相同日剂量分2次给药进行疗效对照,从药效学角度探索加替沙星治疗细菌性感染合理给药方案。方法将142例细菌性感染患者随机分A、B2组,A组采用加替沙星0.4g溶于0.9%氯化钠注射液200ml中缓慢静滴,qd,3天后改为口服0.4g,qd;B组采用加替沙星0.2g溶于0.9%氯化钠注射液100ml中缓慢静滴,bid,3天后改为口服0.2g,bid,2组疗程均为7-10d,观察治疗结束时临床有效率、细菌清除率,及各患者用药过程中出现的各种用药不良反应,并比较2组患者实际用药天数。结果A、B组临床有效率分别为93.59%、87.5%(P<0.05),细菌清除率分别为95.59%、87.27%(P<0.05),2组患者实际用药天数分别为7.2±0.9、9.1±1.7(P<0.05),2组患者用药过程中的药物不良反应发生率分别为7.69%、6.25%(P>0.05).结论加替沙星日单次给药治疗呼吸及泌尿系细菌感染的临床疗效显著优于相同日剂量分2次给药疗效,值得推广。Objective Observing clinical effective of bacterial infection patients treated with gatifloxacin in intravenous drip one day at a time,and comparison with clinical effective of bacterial infection patients treated with the same daily dose of gatifloxacin is in intravenous drip,Bid.And then,exploring a reasonable injection medication of gatifloxacin.Method 142 bacterial infection of patients are divided in A,B groups randomly.A group adopt the 0.4 gram gatifloxacin which is dissolved in the 200ml physiologic...

关 键 词：加替沙星 浓度依赖型 药效学 用法 疗效 

分 类 号：R56[医药卫生—呼吸系统]